Congenital abnormalities
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Congenital abnormalities
Cerebral Palsy Treatment with Stem Cell Therapy
Commonly referred to as CP, cerebral palsy affects the normal movement of different parts of the body and has several degrees of severity. The term “cerebral” speaks of the brain’s cerebrum, a part of the brain that controls motor functions whereas “palsy” refers to paralysis of voluntary movement in specific body parts.
The cerebrum in the brain regulates all types of motor functions that allow you to live independently. Motor functions can be either voluntary or involuntary. When the cerebrum is injured, both voluntary and involuntary fail to function properly hence presenting a range of challenges related to walking, talking or even handling simple everyday tasks independently.
CP is caused by deformity or interruption in the brain development, normally before the child is delivered. In most cases, the exact cause remains unknown but factors that deter brain development include:
- Maternal infection; German measles, chicken pox, herpes toxoplasmosis or any other viral ailment of the mother in early pregnancy
- Gene’s mutations
- Fetal stroke
- Infant infection that leads to inflammation in/around the brain
- Prolonged loss of oxygen (asphyxia) during the perinatal period or delivery process
- Birth injury caused by medical negligence
Stem Cell Treatment for Cerebral Palsy
Mesenchymal Stem Cells (MSCs) are one of the most studied types of stem cells for cerebral palsy treatment. The potential of MSCs:
- They reduce the in ammatory response and avoid secondary brain lesion.
- Differentiate into neurons, astrocyte, microglia, and oligodendrocyte, which help to repair myelin sheath, promoting axon regeneration, and increasing transmission of nerve impulses.
- Produce the cytokines and growth factors, such as glial-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrohin 3 (NT-3), neurotrohin 4/5 (NT 4/5) which promote brain neuroprotection.
- Generate new vessels, thereby increasing the delivery of oxygen and nutrients to injured and hypoxic tissue.
- Reduce the intrinsic cell apoptosis.
Commodi pariatur iusto quasi.